In response to the evolving addiction crisis impacting communities across the state, the S.C. Center of Excellence in Addiction was established in late 2022 by Clemson University, University of South Carolina, Medical University of South Carolina, The Office of Substance Use Services at the Department of Behavioral Health and Developmental Disabilities (BHDD) (formerly the S.C. Department of Alcohol and Other Drug Abuse Services), and The S.C. Department of Public Health (formerly the S.C. Department of Health and Environmental Control).

To combine and more efficiently apply expertise and resources to address opioid use disorder and other substance use disorders, the Center of Excellence operates as one collaborative institution jointly owned and operated by the universities and state agencies.

The Center serves three main functions for South Carolina: opioid abatement support, provider capacity building, and innovation development.